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PERSONAL DETAILS

Title, first name, surname: Dr. Devanjali Dutta

Date of birth: 29/09/1987

ORCID ID: https://orcid.org/0000-0002-4993-9639

LinkedIn: https://nl.linkedin.com/in/devanjali-dutta



CURRENT POSITION



Postdoctoral researcher (Veni grant recipient)

Oncode Institute, Hubrecht Institute (KNAW), Netherlands

Hubrecht logo 460   grip-klant-KNAW560  nwo-logo_175x200

Duration: 01/11/2015 – Present

Supervisor: Prof. Hans Clevers – Clevers lab website

Work description:

  • Host-microbe interaction studies using adult stem cell derived Organoid culture systems
  • Understanding intra-tumor heterogeneity using patient derived organoid clonal lines

 



EDUCATION



  • PhD (Grade 1.0 – very good/excellent, with Distinction)

DKFZ-ZMBH Alliance, University of Heidelberg, Germany

uni-heidelberg-logo     dkfz_logo   hbigs-696x302

Duration: 01/02/2011 – 30/07/2015

Supervisor: Prof. Bruce A. Edgar – Edgar lab website

Title of thesis:

Deciphering the regulatory complexity of the adult Drosophila midgut by regional cell-type specific transcriptome mapping.



  • Visiting PhD student (Invited)

Cornell University, Ithaca, New York, USA

cornell_u_logo  1200px-Cornell_Big_Red_logo.svg

Duration: 01/03/2014 – 01/06/2014

Supervisor: Dr. Nicolas Buchon – Buchon Lab website

Work description:

Developed an interactive database for regional, cell type specific RNASeq profiles of intestinal stem cells and differentiated cells.

Check out the FlyGutSeq website here! 



  • Master in Medical Biotechnology (1st in class, with Distinction)

Manipal Life Sciences Centre, Manipal University, India.

manipal logo

Duration:  15/08/2008 – 30/07/2010

Title of thesis:

Studying allele specific gene expression in Folate pathway genes in differentiating K562 and HL60 human cancer cell lines.

Manipal University website 



PUBLICATIONS



1) Heo, I*., Dutta,D*., Schaefer.D, Iakobachvili., Artegiani,B., Sachs,N., Bowden,G., Hendrickx,A., Peters,P., Riggs,W., O’Connor,R., and Clevers, H. (2018). Intestine and lung organoids as model systems for host-parasite interactions. Nature Microbiology, 3: 814–823. doi: 10.1038/s41564-018-0177-8. Link to paper (IF – 14.17). * Co-first authorship

2) Dutta,D., and Clevers, H. (2017). Organoid culture systems to study host-pathogen interactions. Current Opinion in Immunology, 48:15–22. doi: 10.1016/j.coi.2017.07.012. Link to paper (IF – 8. 3).

3) Dutta,D*., Heo, I*., and Clevers, H (2017). Disease modeling in 3D organoid culture systems. Trends in Molecular Medicine, Vol.23, No.5: 393-410. doi:10.1016/j.molmed.2017.02.007 Link to paper (IF-10.72).

4) Dutta,D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., et al. (2015). Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut. Cell Reports, 1–14. doi: 10.1016/j.celrep.2015.06.009. Link to paper (IF-8.28).

5) Patel, P.H., Dutta,D., & Edgar, B. A. (2015). Niche appropriation by Drosophila intestinal stem cell tumors. Nature Cell Biology, doi: 10.1038/ncb3214. Link to paper (IF-20.06).

6) Dutta,D., Buchon, N., Xiang, J., & Edgar, B.A. (2015). Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations. Link to paper. Current Protocols in Stem Cell Biology, pp. 2F.2.1–2F.2.14.

7) Dutta,D., Xiang, J., & Edgar, B. A. (2013). RNA expression profiling from FACS- isolated cells of the Drosophila intestine. Link to paper. Current Protocols in Stem Cell Biology, 27, Unit2F.2.

8) Korzelius,J., Naumann, S. K., Loza-Coll, M.A., Chan, J. S., Dutta,D., Oberheim, J., Christine Gläßer1, et al (2014). Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells. The EMBO Journal, 33(24), 2967–2982. Link to paper. (IF-9.79).

9) Zhou, J., Florescu, S., Boettcher, A.L., Luo, L., Dutta,D., Kerr, G., et al. (2014). Dpp/Gbb signaling is required for normal intestinal regeneration during infection. Developmental Biology, 399 (2), 189–203. Link to paper. (IF-2.94).

10) Zielke, N., Korzelius, J., Straaten, M V., Bender, K., Schuhknecht,G .,Dutta,D ., Xiang,J., Edgar, BA. (2014). Fly-FUCCI: A Versatile Tool for Studying Cell Proliferation in Complex Tissues. Cell Reports, Volume 7, Issue 2, April 2014, Pages 588-598. Link to paper. (IF-8.28).

11) Kohlmaier, A., Fassnacht, C., Jin, Y., Reuter, H., Begum, J., Dutta,D., Edgar, BA. (2014). Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine. Oncogene, 1–14.doi: 10.1038/onc.2014.16. Link to paper. (IF- 8.45).



 SCHOLARSHIPS/GRANTS

 Scholarship/Grant

 Amount

 Year of award

VENI-NWO – Promising young scientist grant

Veni grant awardee- Link

250,000 €

 2016-2019

University of Heidelberg, Germany (HBIGS) scholarship for Graduate studies

120,000 €

 2011-2015

Cornell University, USA (Invited scholar/ fee exempted)

11,300 $

 2014

Awarded Silver jubilee scholarship for excellence in studies, DRDO, Ministry of Defence, India

4000 ₹

 2004-2005

TRAVEL GRANTS

Scholarship/Grant

Amount

 Year of award

ISSCR Travel grant award, Canada  1000 $  2014
HBIGS Travel grant award, Germany  800 €

 2014

TAC Travel award, Heidelberg University, Germany  500 €

 2011


 

   ACADEMIC ACTIVITIES

  1. Nominated as a “GIBCO Cell Culture Hero” (2018) – spotlights cancer researchers across the globe.
  2. Invited speaker at “Obtaining a Research Grant”- KNAW event, Royal Netherlands Academy of Arts and Sciences (2018).
  3. Delegate at SYStem Symposium for the next generation of Stem Cell Research, Vienna, Austria (2018).
  4. Delegate at Keystone Symposia – Microbiome in Health and Disease, Keystone, Colorado, USA (2017).
  5. Delegate at Wenner-Gren Foundations International symposia – “Host-microbe interactions in the gut: from model organisms to human disease”, Stockholm, Sweden (2016).
  6. Visiting Postdoctoral Researcher – Institut Pasteur, Paris, France (2015).
  7. Delegate at Hydra XI – The European Summer School on Stem Cell & Regenerative Medicine,Hydra, Greece (2015).
  8. Awarded EBC*L certification: The International Certificate for Business Competence – recognized by >25 countries (2015).
  9. Delegate at EMBL Symposia- Frontiers in Stem Cells & Cancer, EMBL, Germany (2015).
  10. Delegate at International Society for Stem Cell Research (ISSCR) – 12th Annual meeting, Vancouver, Canad(2014).
  11. Delegate Drosophila research conference, – 54th Annual meeting, Washington DC, USA (2013).
  12. Academic assistant at Stem cells and Gene therapy research Organization (DRDO), Ministry of Defence, India (2010).

 


TRAININGS & COURSES

  1. EMBO Lab Management course, Utrecht, Netherlands (2017)
  2. FlowJo course for FACS analysis, Heidelberg, Germany (2014)
  3. Basic R and Matlab programming language course, Heidelberg, Germany (2014)
  4. Advanced microscopy course- by Zeiss, DKFZ, Germany (2013)
  5. Authorization for Fluorescence Microscopy (Nikon, Germany) (2013)
  6. FACS Analysis- by BD Biosciences, Heidelberg, Germany (2012)
  7. Advanced course of High throughput Sequencing data analysis – EBI-EMBL, Hinxton, UK (2011)
  8. RNA and ChipSeq Sequencing data analysis- EMBL, Heidelberg, Germany (2011)

TECHNICAL EXPERTISE

Experimental/model systems:

  • Human tissues, mouse, cancer cell lines, Drosophila melanogaster & plants

Cell biology:

  • Adult stem cell derived 3D organoid culture systems – Intestine, Lung, Pancreas and Liver
  • Microinjection
  • Flow cytometry/FACS analysis
  • Immunofluorescence assays and immunohistochemistry, lineage tracing/clonal analysis.
  • Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM)
  • Proficiency in Confocal microscopy – Leica SP8X, SP8, SP5 and Zeiss LSM

Molecular biology:

  • Cell type specific/single cell RNA sequencing
  • DNA sequencing
  • PCR, RT-PCR (reverse transcription-PCR)

Bioinformatics/software:

  • RNASeq data and statistical analysis: DNAStar – QSeq, Genomatix, Partek, edgeR, DESeq, Revigo, Gorilla, and DAVID
  • Adobe Illustrator, Photoshop, ImageJ, GraphPad, FlowJo, Cytoscape
  • Basic knowledge of R and Matlab
  • Bioinformatics tools including Primer designing, promoter region analysis, MicroRNA target prediction and SNP analysis, psi-BLAST, CLUSTAL X, W and other tools available at NCBI.